Almost a decade later and Warren Haynes has never confirmed who this song is about, but a quick glance of the lyrics makes it pretty obvious.
"You reunite with your long lost brothers on an old abandoned ship
There was a time when you brought joy to others
Guess you got caught up in the trip"
"Mr High and Mighty remember when you were low
On the sunny streets of Georgia but that was a long time ago"
"Mr. High and Mighty will you ever join us again
Will we dance and sing together, will we all join hands"
Chris Robinson, I think this is known as "calling you out".